“Estrone is one of two major estrogens in non-pregnant women and is a major estrogen produced by the placenta. The primary ovarian estrogen is estradiol; circulating estrone is derived from ovarian secretion and peripheral conversion from gonadal and adrenal androstenedione (via CYP450 aromatase in lipid tissue). Estrone has lower estrogenic potency than estradiol. Estrone is conjugated to glucuronide or sulfate by the liver and excreted in urine and bile. A change in the estradiol/estrone ratio is a reflection of ovarian senescence and development of menopause.”
References:
22. http://www.questdiagnostics.com/hcp/intguide/EndoMetab/EndoManual_AtoZ_PDFs/Estrone_Serum.pdf
