11-deoxycortisol
See also: http://www.questdiagnostics.com/testcenter/TestDetail.action?ntc=30543
“The differential biochemical diagnosis of congenital adrenal hyperplasia caused by 11-β-hydroxylase deficiency includes finding increased serum concentrations of deoxycorticosterone, 11-desoxycortisol, and androstenedione, and suppressed plasma renin concentrations. The disorder may be treated by the administration of glucocorticoids. An additional use is to evaluate the hypothalamic-pituitary-adrenal axis and pituitary ACTH reserve. 11-deoxycortisol is the immediate precursor of cortisol and follows the same catabolic pathways as cortisol.
This test is often used to evaluate the “hypothalamic-pituitary-adrenal axis and pituitary ACTH reserve. 11-deoxycortisol is the immediate precursor and follows the same catabolic pathways as cortisol. This test can also be used to diagnose congenital adrenal hyperplasia (CAH), an inherited/genetic condition caused by deficiency in the CYP11B1 gene (for 11-beta-hydroxylase). The deficiency is an autosomal recessive trait, associated with low-renin hypertension, hypokalemia, excess androgens (androstenedione, especially), and genital ambiguity in females.
21-deoxycortisol
11-deoxycortisol References:
- http://emedicine.medscape.com/article/2088937
- https://www.labcorp.com/wps/portal/!ut/p/c1/04_SB8K8xLLM9MSSzPy8xBz9CP0os_hACzO_QCM_IwMLXyM3AyNjMycDU2dXQwN3M6B8JG55AwMCuv088nNT9QtyI8oBPK_DWA!!/dl2/d1/L0lDU0NTQ1FvS1VRb0tVUSEvb0NvUUFBSVFKQUFNWWhSbkdjb3dVaFNvSUEhIS9ZQkpKdzQ1NGtzdXlsMHN0eW9RIS83X1VFNFMxSTkzME9HUzIwSVMzTzROMk42NjgwL3ZpZXdUZXN0L3Nob3dBbGxSZXN1bHRz/?testId=3419388&criterion=11-Deoxycortisol%2C+LC%2FMS-MS+%28Endocrine+Sciences%29
- http://questdiagnostics.com/hcp/intguide/EndoMetab/EndoManual_AtoZ_PDFs/11_Deoxycortisol.pdf
21-deoxycortisolReferences:
